TATI - Tübingen Ageing and Tumour Immunology Group

Recent Publications

T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II.

Sbierski-Kind J, Goldeck D, Buchmann N, Spranger J, Volk HD, Steinhagen-Thiessen E, Pawelec G, Demuth I, Spira D. Immun Ageing. 2020 Dec 21;17(1):40. doi: 10.1186/s12979-020-00211-y.

Possible causes of disparities in the risk and outcomes of COVID-19: Cytomegalovirus and aged immune phenotype.

Smith AP, Pawelec G. J Clin Transl Res. 2020 Aug 29;6(3):92-93. eCollection 2020 Sep 5.

Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults.

Verschoor CP, Andrew MK, Loeb M, Pawelec G, Haynes L, Kuchel GA, McElhaney JE. Vaccines (Basel). 2021 Jan 7;9(1):25. doi: 10.3390/vaccines9010025.

Aging in COVID-19: Vulnerability, immunity and intervention.

Chen Y, Klein SL, Garibaldi BT, Li H, Wu C, Osevala NM, Li T, Margolick JB, Pawelec G, Leng SX. Ageing Res Rev. 2020 Oct 30:101205. doi: 10.1016/j.arr.2020.101205. Online ahead of print.

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.

Ladomersky E, Zhai L, Lauing KL, Bell A, Xu J, Kocherginsky M, Zhang B, Wu JD, Podojil JR, Platanias LC, Mochizuki AY, Prins RM, Kumthekar P, Raizer JJ, Dixit K, Lukas RV, Horbinski C, Wei M, Zhou C, Pawelec G, Campisi J, Grohmann U, Prendergast GC, Munn DH, Wainwright DA. Clin Cancer Res. 2020 Oct 1;26(19):5232-5245. doi: 10.1158/1078-0432.CCR-19-3874. Epub 2020 Jun 16.

The conundrum of human immune system "senescence".

Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA. Mech Ageing Dev. 2020 Sep 17;192:111357. doi: 10.1016/j.mad.2020.111357. Online ahead of print.

 Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T. Mech Ageing Dev. 2020 Oct;191:111316. doi: 10.1016/j.mad.2020.111316. Epub 2020 Jul 18.

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults.

Chen S, Pawelec G, Trompet S, Goldeck D, Mortensen LH, Slagboom PE, Christensen K, Gussekloo J, Kearney P, Buckley BM, Ford I, Jukema JW, Westendorp RGJ, Maier AB. J Infect Dis. 2020 Sep 10:jiaa480. doi: 10.1093/infdis/jiaa480. Online ahead of print.

The human immunosenescence phenotype: does it exist?

Pawelec G. Semin Immunopathol. 2020 Aug 5:1-8. doi: 10.1007/s00281-020-00810-3. Online ahead of print.

Invited Editorial: Despite COVID-19, Influenza Must Not Be Relegated to "Only the Sniffles".

Pawelec G. Vaccines (Basel). 2020 Aug 7;8(3):445. doi: 10.3390/vaccines8030445

Immune Signatures and Survival of Patients With Metastatic Melanoma, Renal Cancer, and Breast Cancer.

Wistuba-Hamprecht K, Gouttefangeas C, Weide B, Pawelec G. Front Immunol. 2020 Jun 9;11:1152. doi: 10.3389/fimmu.2020.01152. eCollection 2020.

Exploratory study on immune phenotypes in Alzheimer's disease and vascular dementia.

D'Angelo C, Goldeck D, Pawelec G, Gaspari L, Di Iorio A, Paganelli R. Eur J Neurol. 2020 May 22. doi: 10.1111/ene.14360. Online ahead of print.

The inherent challenges of classifying senescence-Response.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G. Science. 2020 May 8;368(6491):595-596. doi: 10.1126/science.abb4073.

Aging as an inflammatory disease and possible reversal strategies.

Pawelec G. J Allergy Clin Immunol. 2020 May;145(5):1355-1356. doi: 10.1016/j.jaci.2020.02.022. Epub 2020 Mar 4.

The immune response to influenza in older humans: beyond immune senescence.

McElhaney JE, Verschoor CP, Andrew MK, Haynes L, Kuchel GA, Pawelec G. Immun Ageing. 2020 May 7;17:10. doi: 10.1186/s12979-020-00181-1. eCollection 2020.

Recent advances in influenza vaccines.

Pawelec G, McElhaney J. F1000Res. 2020 Apr 28;9:F1000 Faculty Rev-305. doi: 10.12688/f1000research.22611.1. eCollection 2020.

Can an effective SARS-CoV-2 vaccine be developed for the older population?

Pawelec G, Weng NP. Immun Ageing. 2020 Apr 11;17:8. doi: 10.1186/s12979-020-00180-2. eCollection 2020.

Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.

Picard E, Verschoor CP, Ma GW, Pawelec G. Front Immunol. 2020 Mar 6;11:369. doi: 10.3389/fimmu.2020.00369. eCollection 2020.

Pitfalls in the characterization of circulating and tissue-resident human γδ T cells.

Beucke N, Wesch D, Oberg HH, Peters C, Bochem J, Weide B, Garbe C, Pawelec G, Sebens S, Röcken C, Hashimoto H, Löffler MW, Nocerino P, Kordasti S, Kabelitz D, Schilbach K, Wistuba-Hamprecht K.

J Leukoc Biol. 2020 Jan 22. doi: 10.1002/JLB.5MA1219-296R. [Epub ahead of print]

Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women.

Di Benedetto S, Müller L, Rauskolb S, Sendtner M, Deutschbein T, Pawelec G, Müller V.

Immun Ageing. 2019 Dec 4;16:31. doi: 10.1186/s12979-019-0171-x. eCollection 2019.

To help aging populations, classify organismal senescence.

 Stuart R. G. Calimport, Barry L. Bentley, Claire E. Stewart, Graham Pawelec, Angelo Scuteri, Manlio Vinciguerra, Cathy Slack, Danica Chen, Lorna W. Harries, Gary Marchant, G. Alexander Fleming, Michael Conboy, Adam Antebi, Gary W. Small, Jesus Gil, Edward G. Lakatta, Arlan Richardson, Clifford Rosen, Karoly Nikolich, Tony Wyss-Coray, Lawrence Steinman, Thomas Montine, João Pedro de Magalhães, Judith Campisi, George Church.

Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319


Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade.

Bochem J, Zelba H, Amaral T, Spreuer J, Soffel D, Eigentler T, Wagner NB, Uslu U, Terheyden P, Meier F, Garbe C, Pawelec G, Weide B, Wistuba-Hamprecht K.

PLoS One. 2019 Aug 16;14(8):e0221301. doi: 10.1371/journal.pone.0221301. eCollection 2019.

Are skin senescence and immunosenescence linked within individuals?

Waaijer MEC, Goldeck D, Gunn DA, van Heemst D, Westendorp RGJ, Pawelec G, Maier AB.

Aging Cell. 2019 Aug;18(4):e12956. doi: 10.1111/acel.12956. Epub 2019 May 6.

Editorial: Immunology of Aging.

Pawelec G, Gupta S.

Front Immunol. 2019 Jul 10;10:1614. doi: 10.3389/fimmu.2019.01614. eCollection 2019.

Frequency of Immune Cell Subtypes in Peripheral Blood Correlates With Outcome for Patients With Metastatic Breast Cancer Treated With High-Dose Chemotherapy.

Lafrenie RM, Speigl L, Buckner CA, Pawelec G, Conlon MS, Shipp C.

Clin Breast Cancer. 2019 Dec;19(6):433-442. doi: 10.1016/j.clbc.2019.05.002. Epub 2019 May 27.

Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity.

Pawelec G, Verschoor CP, Ostrand-Rosenberg S.

Front Immunol. 2019 May 15;10:1099. doi: 10.3389/fimmu.2019.01099. eCollection 2019. Review.

Zoster vaccination in older adults: efficacy and public health implications.

McElhaney JE, Verschoor C, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2019 Apr 4. pii: glz085. doi: 10.1093/gerona/glz085. [Epub ahead of print]

Research on immunity and ageing comes of age.

Weng NP, Pawelec G.

Immun Ageing. 2019 Apr 29;16:8. doi: 10.1186/s12979-019-0148-9. eCollection 2019.

Is There a Positive Side to T Cell Exhaustion?

Pawelec G.

Front Immunol. 2019 Jan 29;10:111. doi: 10.3389/fimmu.2019.00111. eCollection 2019. Review.

Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications.

Andrew MK, Bowles SK, Pawelec G, Haynes L, Kuchel GA, McNeil SA, McElhaney JE.

Drugs Aging. 2019 Jan;36(1):29-37. doi: 10.1007/s40266-018-0597-4. Review.

Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium.

Pawelec G.

Biogerontology. 2018 Dec;19(6):537-545. doi: 10.1007/s10522-017-9739-z. Epub 2017 Nov 28.

Unexpected Benefits of Aging for Favorable Responses to PD-1 Blockade in Melanoma?

Pawelec G.

Clin Cancer Res. 2018 Nov 1;24(21):5193-5194. doi: 10.1158/1078-0432.CCR-18-1475. Epub 2018 Jun 15.

Low levels of intra-tumoural T cells in breast cancer identify clinically frail patients with shorter disease-specific survival.

Speigl L, Grieb A, Janssen N, Hatse S, Brouwers B, Smeets A, Floris G, Bailur JK, Kenis C, Neven P, Wildiers H, Pawelec G, Shipp C.

J Geriatr Oncol. 2018 Nov;9(6):606-612. doi: 10.1016/j.jgo.2018.03.021. Epub 2018 Apr 21.

Accurate quantification of T-cells expressing PD-1 in patients on anti-PD-1 immunotherapy.

Zelba H, Bochem J, Pawelec G, Garbe C, Wistuba-Hamprecht K, Weide B.

Cancer Immunol Immunother. 2018 Sep 14. doi: 10.1007/s00262-018-2244-7. [Epub ahead of print]

CASIN the joint: immune aging at the stem cell level.

Pawelec GP.

Blood. 2018 Aug 9;132(6):553-554. doi: 10.1182/blood-2018-06-858696.

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer's Disease?

Fulop T, Witkowski JM, Bourgade K, Khalil A, Zerif E, Larbi A, Hirokawa K, Pawelec G, Bocti C, Lacombe G, Dupuis G, Frost EH.

Front Aging Neurosci. 2018 Jul 24;10:224. doi: 10.3389/fnagi.2018.00224. eCollection 2018

Does patient age influence anti-cancer immunity?

Pawelec G.

Semin Immunopathol. 2018 Jul 13. doi: 10.1007/s00281-018-0697-6. [Epub ahead of print] Review.

Role of the peripheral innate immune system in the development of Alzheimer's disease.

Le Page A, Dupuis G, Frost EH, Larbi A, Pawelec G, Witkowski JM, Fulop T.

Exp Gerontol. 2018 Jul 1;107:59-66. doi: 10.1016/j.exger.2017.12.019. Epub 2017 Dec 21. Review.

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells.

Teteloshvili N, Dekkema G, Boots AM, Heeringa P, Jellema P, de Jong D, Terpstra M, Brouwer E, Pawelec G, Kok K, van den Berg A, Kluiver J, Kroesen BJ.

Front Immunol. 2018 Jun 18;9:1400. doi: 10.3389/fimmu.2018.01400. eCollection 2018.

Relationships between the inflammatory potential of the diet, aging and anthropometric measurements in a cross-sectional study in Pakistan.

Alam I, Shivappa N, Hebert JR, Pawelec G, Larbi A.

Nutr Healthy Aging. 2018 Jun 15;4(4):335-343. doi: 10.3233/NHA-180042.

Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells.

Janssen N, Speigl L, Pawelec G, Niessner H, Shipp C.

Cell Immunol. 2018 May;327:68-76. doi: 10.1016/j.cellimm.2018.02.012. Epub 2018 Feb 21.

Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe.

Pawelec G.

Mech Ageing Dev. 2018 Apr 11. pii: S0047-6374(18)30054-X. doi: 10.1016/j.mad.2018.04.005. [Epub ahead of print]

CD14+ HLA-DR-/low MDSCs are elevated in the periphery of early-stage breast cancer patients and suppress autologous T cell proliferation.

Speigl L, Burow H, Bailur JK, Janssen N, Walter CB, Pawelec G, Shipp C.

Breast Cancer Res Treat. 2018 Apr;168(2):401-411. doi: 10.1007/s10549-017-4594-9. Epub 2017 Dec 11.

Immune signatures predicting responses to immunomodulatory antibody therapy.

Pawelec G.

Curr Opin Immunol. 2018 Apr;51:91-96. doi: 10.1016/j.coi.2018.03.003. Epub 2018 Mar 15.

Vaccines for Improved Cellular Immunity to Influenza.

Pawelec G, McElhaney J.

EBioMedicine. 2018 Apr;30:12-13. doi: 10.1016/j.ebiom.2018.03.001. Epub 2018 Mar 5

Immune correlates of clinical outcome in melanoma.

Pawelec G.

Immunology. 2018 Apr;153(4):415-422. doi: 10.1111/imm.12870. Epub 2017 Dec 20. Review.

Activities 2019

1) Manchester Cancer Research Center Visiting Professor Lecture (MCRC
Seminar series), 20th February, 2019, see http://www.mcrc.manchester.ac.uk/Events

2) "Peripheral Blood Immune Signatures Predicting Response To
Immunomodulatory Antibody Therapy In Melanoma" at Oxford Global's 14th
Annual Biomarkers Congress, Manchester, UK (21,22 February, 2019), see

3) “Immunotherapy of Cancer: Triumphs and Challenges and the Impact of
Immunosenescence” at the 2nd EACR Conference “Defence is the Best
Attack: Immuno-Oncology Breakthroughs”, 11 – 13 March 2019, Barcelona,
Spain, see https://www.eacr.org/conference/immunooncology19/scientific-programme

4) Consultation at the Seqirus Influenza Vaccines Advisory Board
meeting on different influenza vaccine technologies, Barcelona, 14th
March, 2019.

5) "Chairperson’s Opening Remarks" Graham Pawelec, MA, PhD, FGSA,
Professor of Experimental Immunology, Second Department of Internal
Medicine, University of Tuebingen Clinical School, Germany; Affiliated
Scientist, Cancer Solutions Program, Health Sciences North Research
Institute, Canada


"Aging and the Human Immune System in the Era of Immunomodulatory
Antibody Therapy for Cancer: Is It All Downhill?"

It is “common knowledge” that the human immune system deteriorates
over time, resulting in an increased frequency of and susceptibility
to infectious disease, autoimmunity and cancer, and in poorer
responses to vaccines in the elderly (immunosenescence). This
presentation will consider the clinically highly relevant question of
the impact of immune aging on the responses of cancer patients to
immunomodulatory antibody therapy that is currently revolutionizing
medical oncology (2018 Nobel Prize) at Cambridge Healthtech
Institute’s Inaugural Biomarkers for Immuno-Oncology: Exploring
Mechanisms of Predictive and Therapeutic Response, 18-19 March 2019,
London, UK. See https://www.immuno-oncologyeurope.com/biomarkers-immuno-oncology

6) Lecture at Undoing Aging 2019, title TBD, 28-30 March, Berlin,
Germany (see https://www.undoing-aging.org/program.html) and see video of presentation at https://youtu.be/fb1yiTEMStk

7) “Aging and the human immune system in the era of immunomodulatory
antibody therapy for cancer: Is it all downhill?” at the 10th Cancer
Immunotherapy and Immunomonitoring Conference (CITIM), April 29th-May
2nd, 2019, Tblisi, Georgia. See https://www.canceritim.org/speakers/

8) Chairing and lectures at Progress in Vaccination against Cancer 19
and 2nd PIVAC Summer School, 7-9, 10-12 June, 2019, Athens, Greece. See

9) "Interplay between age, immunity, cancer and CMV". Lecture at Systems Biology of Aging conference, JAX Labs, Farmington, CT, 4-5 September, 2019. see www.jax.org/SystemsBiologyofAging 

10) "Ageing and the human immune system". Lecture at Immunotherapy 2019, Florianopolis, Brazil, 29 September-2 October, 2019, see https://sbicongressos.com/immuno2019/


11) Co-Organiser, Society for Immunotherapy of Cancer Young Investigator Symposium, National Harbor, MD, 6 November, 2019, see https://www.sitcancer.org/2019/program/pre-conference-programs/wic


12) "Interplay between age, immunity, cancer and CMV " at Biology of Aging: Understanding Aging to better intervene, 9-11 November, Montreal, Canada, see  https://www.fourwav.es/view/1393/info/

13) "Ageing and the human immune system in the era of immunomodulatory
antibody therapy for cancer: is it all downhill?" at New Technologies and Strategies to fight cancer, 20-22 November, 2019, Rome, Italy, see https://www.adriacongrex.it/en/alliance-against-cancer/


14) "Immunotherapy of cancer: triumphs and challenges, and the impact of immunosenescence in humans - is ageing always a bad thing?" at the 5th Athens  Symposium on Cancer Immunology and Immunotherapy, 5-7 December, 2019, Athens, Greece, see https://www.scep.gr/events/event/3rd-annual-meeting-on-cancer-biologyand-new-molecules-in-cancer-therapeutics/



You can find a complete list of previous activities on this website.