TATI - Tübingen Ageing and Tumour Immunology Group (1994 -2018)

The Tübingen Ageing and Tumour Immunology Group (TATI) conducted research into human immunosenescence, vaccination, tumor immunity, immunotherapy, Alzheimer disease, longevity, immunity and aging.

 

From 2019, TATI will consist only of Graham Pawelec, Professor of Experimental Immunology, Emeritus, Tübingen; affiliated with Health Sciences North Research Institute, Sudbury, Ontario, Canada; Visiting Professor at Nottingham Trent University, King´s College London, and Manchester University, UK. On 1st May, 2019, he became a member of the Department of Immunology, University of Tübingen, Tübingen, Germany.

 

From 1st January 2019, Nan-ping Weng (National Institute on Aging, NIH, US) and Graham Pawelec took over the co-Editorship of the journal "Immunity and Aging" (https://immunityageing.biomedcentral.com/) from founding Editor Calogero Caruso.

 

 

 

Recent Publications

Are skin senescence and immunosenescence linked within individuals?

Waaijer MEC, Goldeck D, Gunn DA, van Heemst D, Westendorp RGJ, Pawelec G, Maier AB.

Aging Cell. 2019 May 6:e12956. doi: 10.1111/acel.12956. [Epub ahead of print]

Zoster vaccination in older adults: efficacy and public health implications.

McElhaney JE, Verschoor C, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2019 Apr 4. pii: glz085. doi: 10.1093/gerona/glz085. [Epub ahead of print]

Is There a Positive Side to T Cell Exhaustion?

Pawelec G.

Front Immunol. 2019 Jan 29;10:111. doi: 10.3389/fimmu.2019.00111. eCollection 2019. Review.

Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications.

Andrew MK, Bowles SK, Pawelec G, Haynes L, Kuchel GA, McNeil SA, McElhaney JE.

Drugs Aging. 2018 Nov 9. doi: 10.1007/s40266-018-0597-4. [Epub ahead of print] Review.

Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium.

Pawelec G.

Biogerontology. 2018 Dec;19(6):537-545. doi: 10.1007/s10522-017-9739-z. Epub 2017 Nov 28.

Unexpected Benefits of Aging for Favorable Responses to PD-1 Blockade in Melanoma?

Pawelec G.

Clin Cancer Res. 2018 Nov 1;24(21):5193-5194. doi: 10.1158/1078-0432.CCR-18-1475. Epub 2018 Jun 15.

Low levels of intra-tumoural T cells in breast cancer identify clinically frail patients with shorter disease-specific survival.

Speigl L, Grieb A, Janssen N, Hatse S, Brouwers B, Smeets A, Floris G, Bailur JK, Kenis C, Neven P, Wildiers H, Pawelec G, Shipp C.

J Geriatr Oncol. 2018 Nov;9(6):606-612. doi: 10.1016/j.jgo.2018.03.021. Epub 2018 Apr 21.

Accurate quantification of T-cells expressing PD-1 in patients on anti-PD-1 immunotherapy.

Zelba H, Bochem J, Pawelec G, Garbe C, Wistuba-Hamprecht K, Weide B.

Cancer Immunol Immunother. 2018 Sep 14. doi: 10.1007/s00262-018-2244-7. [Epub ahead of print]

CASIN the joint: immune aging at the stem cell level.

Pawelec GP.

Blood. 2018 Aug 9;132(6):553-554. doi: 10.1182/blood-2018-06-858696.

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer's Disease?

Fulop T, Witkowski JM, Bourgade K, Khalil A, Zerif E, Larbi A, Hirokawa K, Pawelec G, Bocti C, Lacombe G, Dupuis G, Frost EH.

Front Aging Neurosci. 2018 Jul 24;10:224. doi: 10.3389/fnagi.2018.00224. eCollection 2018

Does patient age influence anti-cancer immunity?

Pawelec G.

Semin Immunopathol. 2018 Jul 13. doi: 10.1007/s00281-018-0697-6. [Epub ahead of print] Review.

Role of the peripheral innate immune system in the development of Alzheimer's disease.

Le Page A, Dupuis G, Frost EH, Larbi A, Pawelec G, Witkowski JM, Fulop T.

Exp Gerontol. 2018 Jul 1;107:59-66. doi: 10.1016/j.exger.2017.12.019. Epub 2017 Dec 21. Review.

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells.

Teteloshvili N, Dekkema G, Boots AM, Heeringa P, Jellema P, de Jong D, Terpstra M, Brouwer E, Pawelec G, Kok K, van den Berg A, Kluiver J, Kroesen BJ.

Front Immunol. 2018 Jun 18;9:1400. doi: 10.3389/fimmu.2018.01400. eCollection 2018.

Relationships between the inflammatory potential of the diet, aging and anthropometric measurements in a cross-sectional study in Pakistan.

Alam I, Shivappa N, Hebert JR, Pawelec G, Larbi A.

Nutr Healthy Aging. 2018 Jun 15;4(4):335-343. doi: 10.3233/NHA-180042.

Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells.

Janssen N, Speigl L, Pawelec G, Niessner H, Shipp C.

Cell Immunol. 2018 May;327:68-76. doi: 10.1016/j.cellimm.2018.02.012. Epub 2018 Feb 21.

Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe.

Pawelec G.

Mech Ageing Dev. 2018 Apr 11. pii: S0047-6374(18)30054-X. doi: 10.1016/j.mad.2018.04.005. [Epub ahead of print]

CD14+ HLA-DR-/low MDSCs are elevated in the periphery of early-stage breast cancer patients and suppress autologous T cell proliferation.

Speigl L, Burow H, Bailur JK, Janssen N, Walter CB, Pawelec G, Shipp C.

Breast Cancer Res Treat. 2018 Apr;168(2):401-411. doi: 10.1007/s10549-017-4594-9. Epub 2017 Dec 11.

Immune signatures predicting responses to immunomodulatory antibody therapy.

Pawelec G.

Curr Opin Immunol. 2018 Apr;51:91-96. doi: 10.1016/j.coi.2018.03.003. Epub 2018 Mar 15.

Vaccines for Improved Cellular Immunity to Influenza.

Pawelec G, McElhaney J.

EBioMedicine. 2018 Apr;30:12-13. doi: 10.1016/j.ebiom.2018.03.001. Epub 2018 Mar 5

Immune correlates of clinical outcome in melanoma.

Pawelec G.

Immunology. 2018 Apr;153(4):415-422. doi: 10.1111/imm.12870. Epub 2017 Dec 20. Review.

Activities 2019

1) Manchester Cancer Research Center Visiting Professor Lecture (MCRC
Seminar series), 20th February, 2019, see http://www.mcrc.manchester.ac.uk/Events

2) "Peripheral Blood Immune Signatures Predicting Response To
Immunomodulatory Antibody Therapy In Melanoma" at Oxford Global's 14th
Annual Biomarkers Congress, Manchester, UK (21,22 February, 2019), see
https://www.oxfordglobal.co.uk/biomarkers-congress/

3) “Immunotherapy of Cancer: Triumphs and Challenges and the Impact of
Immunosenescence” at the 2nd EACR Conference “Defence is the Best
Attack: Immuno-Oncology Breakthroughs”, 11 – 13 March 2019, Barcelona,
Spain, see https://www.eacr.org/conference/immunooncology19/scientific-programme

4) Consultation at the Seqirus Influenza Vaccines Advisory Board
meeting on different influenza vaccine technologies, Barcelona, 14th
March, 2019.

5) "Chairperson’s Opening Remarks" Graham Pawelec, MA, PhD, FGSA,
Professor of Experimental Immunology, Second Department of Internal
Medicine, University of Tuebingen Clinical School, Germany; Affiliated
Scientist, Cancer Solutions Program, Health Sciences North Research
Institute, Canada

and

"Aging and the Human Immune System in the Era of Immunomodulatory
Antibody Therapy for Cancer: Is It All Downhill?"

It is “common knowledge” that the human immune system deteriorates
over time, resulting in an increased frequency of and susceptibility
to infectious disease, autoimmunity and cancer, and in poorer
responses to vaccines in the elderly (immunosenescence). This
presentation will consider the clinically highly relevant question of
the impact of immune aging on the responses of cancer patients to
immunomodulatory antibody therapy that is currently revolutionizing
medical oncology (2018 Nobel Prize) at Cambridge Healthtech
Institute’s Inaugural Biomarkers for Immuno-Oncology: Exploring
Mechanisms of Predictive and Therapeutic Response, 18-19 March 2019,
London, UK. See https://www.immuno-oncologyeurope.com/biomarkers-immuno-oncology

6) Lecture at Undoing Aging 2019, title TBD, 28-30 March, Berlin,
Germany (see https://www.undoing-aging.org/program.html)

7) “Aging and the human immune system in the era of immunomodulatory
antibody therapy for cancer: Is it all downhill?” at the 10th Cancer
Immunotherapy and Immunomonitoring Conference (CITIM), April 29th-May
2nd, 2019, Tblisi, Georgia. See https://www.canceritim.org/speakers/

8) Chairing and lectures at Progress in Vaccination against Cancer 19
and 2nd PIVAC Summer School, 7-9, 10-12 June, 2019, Athens, Greece. See
https://pivac19.eu/
https://ssio2019.eu/

   

You can find a complete list of  recent activites  or  previous activities  on this website.