TATI - Tübingen Ageing and Tumour Immunology Group

The Tübingen Ageing and Tumour Immunology Group (TATI) conducts research in human immunosenescence, vaccination, tumor immunity, immunotherapy, Alzheimer disease, longevity, immunity and aging. Our expertise is in polychromatic flow cytometry, T cell cloning, confocal microscopy, proteomics, signal transduction, hypoxia, antigen identification, immune monitoring, cancer vaccination, influenza vaccination.

Recent Publications

Wistuba-Hamprecht K, Martens A, Heubach F, Romano E, Geukes Foppen M, Yuan J, Postow M, Wong P, Mallardo D, Schilling B, Di Giacomo AM, Khammari A, Dreno B, Maio M, Schadendorf D, Ascierto PA, Wolchok JD, Blank CU, Garbe C, Pawelec G, Weide B.

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients.

Eur J Cancer. 2017 Mar;73:61-70.  [Epub 2017 Feb 4]

Bailur JK, Pawelec G, Hatse S, Brouwers B, Smeets A, Neven P, Laenen A, Wildiers H, Shipp C.

Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty.

Breast Cancer Res. 2017 Feb 28;19(1):20.  [PubMed - in process]

Pawelec G.

Immunosenescence and cancer.

Biogerontology. 2017 Feb 20.  [Epub ahead of print]

Di Benedetto S, Müller L, Wenger E, Düzel S, Pawelec G.

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions.

Neurosci Biobehav Rev. 2017 Feb 1. pii: S0149-7634(16)30775-8.  [Epub ahead of print]

Wistuba-Hamprecht K, Martens A, Weide B, Teng KW, Zelba H, Guffart E, Chen J, Garbe C, Newell EW, Larbi A, Pawelec G.

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients.

J Immunol. 2016 Dec 16. pii: 1600875.  [Epub ahead of print]

Fülöp T, Herbein G, Cossarizza A, Witkowski JM, Frost E, Dupuis G, Pawelec G, Larbi A.

Cellular Senescence, Immunosenescence and HIV.

Interdiscip Top Gerontol Geriatr. 2017;42:28-46.  [Epub 2016 Nov 22]

There is a complete list of the publication since 2012 of the TATI Group on the website.

Recent and Future Activities

Nov 14, 2016: G. Pawelec: "Immunity and ageing: causes and consequences of immunosenescence in humans."

Departmental Seminar, Center for Aging, Tulane University, New Orleans, USA; invited by Prof. M. Jaswinski.

Oct 19, 2016: G. Pawelec:"Immune Parameters Associated with Mortality in the Elderly are Context-Dependent: Lessons from Sweden, Holland and Belgium."

Lecture at the Biology of Aging: Paving the way for healthy aging conference, Montreal, CAN;  invited by Prof. T. Fülöp. 

Sep 30-Oct 1, 2016: "Adult Vaccines European Futuring Collaborative" , organized by Pfizer in Zurich (SUI).

Interview with Prof. Pawelec  [Video].

Sep 26, 2016: G. Pawelec: "Clonal T cell cultures as models of immune cell ageing."

Lecture at the Cell Fates and Aging Conference, Dubrovnik-Cavtat, Croatia; invited by Profs. J. Campisi and J. Vijg.

Sep 23, 2016:  G. Pawelec:  "Immunosenescence and cancer."

Lecture at the 10th European Biogerontology Congress, Warsaw, PL; invited by Prof. E. Sikora.

Sep 16, 2016: G. Pawelec: "Immunotherapy of Cancer: Triumphs and Challenges."

Visiting Professor Lecture at Nottingham Trent University, Nottingham, UK; invited by Prof. G. Pockley. 

Aug 11, 2016: G. Pawelec: "Immunosenescence and Cancer: is there an 'Immune Risk Profile' in cancer and ageing?"

Lecture at Health Sciences North Research Institute, Sudbury, ON, Canada; invited by Dr J. McElhaney.

Aug 2, 2016: Kilian Wistuba-Hamprecht after the defence of his thesis.

Prof. Pawelec  put the hat on Kilian, while Prof. Rammensee was looking on with friends and colleagues.

Future Activities

G. Pawelec will be attending the following meetings in 2017:

(last update Mar 7, 2017) 

1.-5.4.  Washington DC (attending AACR Annual Meeting)

Prague (Keynote at CITIM)


Rome (speaking at Hematologic Diseases in the Elderly)


Barcelona (speaking at the EHA meeting)


Co-organiser of the Satellite Symposium on “Aging of the Immune System”


Washington DC (attending the AAI Annual Congress)


Paris (presenting at NICIS)


Chicago (attending FOCIS)



 Madrid (presenting ""A Clinical And Biological Perspective Of Human

 Myeloid-derived Suppressor cells in cancer" at the 22nd EHA conference)


 Exeter (presenting at the BSRA annual meeting


San Francisco (co-organising a session at the IAGG Conference)  


Loutraki, Greece (PIVAC 17)


Athens (presenting at “Molecular Aspects of Aging and Longevity”)

G. Pawelec will be attending the following meetings in 2018:

(last update November 18, 2016)



Austin, TX (co-organizer of the Keystone Symposium "Aging, Inflammation and  Immunity")


You can find a complete list of  recent activites  or  previous activities  on this website.