TATI - Tübingen Ageing and Tumour Immunology Group

The Tübingen Ageing and Tumour Immunology Group (TATI) conducts research in human immunosenescence, vaccination, tumor immunity, immunotherapy, Alzheimer disease, longevity, immunity and aging. Our expertise is in polychromatic flow cytometry, T cell cloning, confocal microscopy, proteomics, signal transduction, hypoxia, antigen identification, immune monitoring, cancer vaccination, influenza vaccination.

Recent Publications

Fulop T, Witkowski JM, Le Page A, Fortin C, Pawelec G, Larbi A.

Intracellular signaling pathways: Targets to reverse immunosenescence.

Clin Exp Immunol. 2016 Jul 1.  [Epub ahead of print]

Shipp C, Speigl L, Janssen N, Martens A, Pawelec G.

A clinical and biological perspective of human myeloid-derived suppressor cells in cancer.

Cell Mol Life Sci. 2016 May 28.  [Epub ahead of print]

Kini Bailur J, Gueckel B, Pawelec G.

Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer.

J Transl Med. 2016 May 28;14(1):151.  [PubMed]

Aiello AE, Feinstein L, Dowd JB, Pawelec G, Derhovanessian E, Galea S, Uddin M, Wildman DE, Simanek AM.

Income and Markers of Immunological Cellular Aging.

Psychosom Med. 2016 May 16.  [Epub ahead of print]

Martens A, Wistuba-Hamprecht K, Yuan J, Postow MA, Wong P, Capone M, Madonna G, Khammari A, Schilling B, Sucker A, Schadendorf D, Martus P, Dreno B, Ascierto PA, Wolchok JD, Pawelec G, Garbe C, Weide B.

Increases in absolute lymphocytes and circulating CD4+ and CD8+ T cells are associated with positive clinical outcome of melanoma patients treated with ipilimumab.

Clin Cancer Res. 2016 May 11.   [Epub ahead of print]

There is a complete list of the publication since 2012 of the TATI Group on the website.

Recent and Future Activities

Jun 16-19, 2016: Graham Pawelec was a speaker at the Regulatory Myeloid Suppressor Cells Conference in in Philadelphia, PA (USA).

Announcement of the MDSC Conference.
Wistar Reg Myeloid SuppCell Conf gnl.pdf
Adobe Acrobat Document 272.4 KB

April 1, 2016: G. Pawelec became at visiting professor

in the Division of Cancer Studies, Faculty of Life Sciences and Medicine, King’s College London, UK.

March 3, 2016: G. Pawelec: "Immunosenescence and Cancer: is there an 'Immune Risk Profile' in cancer and ageing?"

A lecture at the Manchester Immunology Group, invited by Prof. M. Exley, Manchester, UK.

March 2016: Fakhri Hassouneh, PhD student, from Cordoba, Spain, is visiting scientist

on a DAAD grant working on the role of Cytomegalovirus in immunosenescence.

Feb 9-11, 2016: G. Pawelec: "Immunity and Ageing: causes and consequences of immunosenescence in humans."

A talk at the international summit “Ageing 2016” in London, UK:

Jan 29,  2016: G. Pawelec: "The Clinical Impact of Immunosenescence on Kidney Transplantation." 

Lecture at the 16th Canadian Kidney Transplant Forum, invited by Prof. J. Shapiro. Montreal, CA. 

Jan 18, 2016: G. Pawelec:  “Immunity and ageing: causes and consequences of immunosenescence in humans.”

Presentation at the Departmental Seminar, University of Groningen, invited by Prof. A. van den Berg. Groningen, Holland.

Dec 14, 2015: G. Pawelec:  “Why do we age?”

Departmental seminar, University of Athens, invited by Prof. O. Tsitsilonis. Athens, Greece.

Dec 9-10, 2015: G. Pawelec & C. Shipp attend the Greek-German Days on Research, Innovation & Young Scientists" at the National Hellenic Research Foundation (NHRF) in Athens, Greece.

The poster entitled "Immune signatures within the tumor and in the peripheral blood as prognostic/predictive biomarkers in Breast Cancer" by Sotirios P. Fortis, Christopher Shipp, Constantin N. Baxevanis, Graham Pawelec won the Young Scientists Poster Prize.

Dec 5, 2015: G. Pawelec: “Antigen-specific T cells, MDSCs and survival in melanoma and breast cancer”

Presentation at the Immunotherapy Bridge, invited by Prof. P. Ascierto. Naples, Italy.

Nov 21, 2015: G. Pawelec: “Immune status of BASE-II donors: associations with socioeconomic score.”

Symposium presentation at the GSA Annual Meeting, invited by Dr. C. Krekel. Orlando (FL), USA.

Nov 5, 2015: G. Pawelec: “Immunity and ageing: causes and consequences of immunosenescence in humans.”

Johns Hopkins Seminar, invited by Prof. S Leng. Baltimore (MD), USA.

Nov 4-8, 2015: Society for Immunotherapy of Cancer (SITC 2015) in National Harbor (MD), USA.

Poster and Presentation from Chris Shipp at SITC2015:

Chris Shipp spoke about his poster at the pre-SITC WIC (World Immunotherapy Council) meeting:  "Can the peripheral immune profile in breast cancer patients be used to predict tumour antigen T cell responses?" His second poster was: “Relationship between the Peripheral Immune Profile and Tumour Antigen T Cell Responses in Breast Cancer Patients.” Chris Shipp was selected as "International Scholar". 

Poster from Nicole Janssen at the SITC2015:

Nicole Janssen, Graham Pawelec, Lisa Speigl, Sotirios P Fortis, Christoforos Haritos, Sonia A Perez, Constantin N Baxevanis, Jithendra Kini Bailur, Christopher Shipp.

Immune profiling of breast cancer patients: relationship between tumour antigen T cell responses with suppressor and effector leukocyte populations.

Oct 30, 2015: G. Pawelec: “Immunosenescence and Cancer: is there an ‘Immune Risk Profile’ in cancer and ageing?”

Keynote Lecture at “Advances in cancer Immunology and immunotherapy”, invited by Prof. O. Tstitsilonis. Athens, Greece.

Oct 30, 2015: G. Pawelec: “Antigen-specific T cells, MDSCs and survival in melanoma and breast cancer.”

Lecture at “Advances in cancer Immunology and immunotherapy”, invited by Prof. O. Tstitsilonis. Athens, Greece.

Oct 23, 2015: G. Pawelec:  “Why do we age?” 

Presentation at the "Biology of Aging" Conference, invited by Dr. A. Larbi, Singapore. 

Sep 5, 2015: G. Pawelec:  “In vitro models of human T cell senescence.”

Presentation at Immunosenescence Satellite Symposium, invited by Dr. B. Weinberger. Vienna, Austria.

Aug 19, 2015: G. Pawelec:  “Senescence, Immunosenescence and Cancer.”

Visiting Professor lecture, invited by Prof. Y. Barnett. Nottingham Trent University, Nottingham, UK. 

Future Activities

G. Pawelec will be attending the following meetings in 2016:

(last update July 6, 2016)


14.-21.6.      Philadelphia (MDSC conference)

9.-13.7.        Manchester (EACR conference)

17.-22.7.     Bethesda (NIH review panel)

11.-15.9.     Winchester (PIVAC 16)

15.-18.9.     Nottingham (VP meeting)

22.-25.9.     Warsaw (ECB10 meeting)

12.-16.10.   Siena (NIBIT)

17.-19.10.   Montreal (Tamas 2nd Ageing meeting)

20.-25.10.   Boston (AACR Tumor Immunology meeting)

8.-13.11.      National Harbor (SITC)

15.-21.11.    New Orleans (GSA)

5.-10.12.      Liverpool (BSI/Dutch Immunol Soc meeting)

14.-18.12.    Athens (Oncoimmunology meeting)

You can find a complete list of  recent activites  or  previous activities  on this website.