Publications of the TATI Group since 2012

Last update  Mar 6, 2017. For a complete list of publications see Graham Pawelec's CV.


Bailur JK, Pawelec G, Hatse S, Brouwers B, Smeets A, Neven P, Laenen A, Wildiers H, Shipp C.

Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty.

Breast Cancer Res. 2017 Feb 28;19(1):20.  [PubMed - in process]

Pawelec G.

Immunosenescence and cancer.

Biogerontology. 2017 Feb 20.  [Epub ahead of print]

Wistuba-Hamprecht K, Martens A, Heubach F, Romano E, Geukes Foppen M, Yuan J, Postow M, Wong P, Mallardo D, Schilling B, Di Giacomo AM, Khammari A, Dreno B, Maio M, Schadendorf D, Ascierto PA, Wolchok JD, Blank CU, Garbe C, Pawelec G, Weide B.

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients.

Eur J Cancer. 2017 Mar;73:61-70.  [Epub 2017 Feb 4]

Di Benedetto S, Müller L, Wenger E, Düzel S, Pawelec G.

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions.

Neurosci Biobehav Rev. 2017 Feb 1. pii: S0149-7634(16)30775-8.  [Epub ahead of print]

Fülöp T, Herbein G, Cossarizza A, Witkowski JM, Frost E, Dupuis G, Pawelec G, Larbi A.

Cellular Senescence, Immunosenescence and HIV.

Interdiscip Top Gerontol Geriatr. 2017;42:28-46.  [Epub 2016 Nov 22]


Wistuba-Hamprecht K, Martens A, Weide B, Teng KW, Zelba H, Guffart E, Chen J, Garbe C, Newell EW, Larbi A, Pawelec G.

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients.

J Immunol. 2016 Dec 16. pii: 1600875.  [Epub ahead of print]

Adriaensen W, Pawelec G, Vaes B, Hamprecht K, Derhovanessian E, van Pottelbergh G, Degryse JM, Matheï C.

CD4:8 Ratio Above 5 Is Associated With All-Cause Mortality in CMV-Seronegative Very Old Women: Results From the BELFRAIL Study.

J Gerontol A Biol Sci Med Sci. 2016 Dec 7. pii: glw215.  [Epub ahead of print]

Goldeck D, Larsen LA, Christiansen L, Christensen K, Hamprecht K, Pawelec G, Derhovanessian E.

Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection.

J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1537-1543. Epub 2016 Jan 11.  [PubMed]

Speigl L, Janssen N, Weide B, Pawelec G, Shipp C.

Prognostic impact of the putative cancer stem cell markers ABCG2, CD133, ALDH1A1 and CD44V7/8 in metastatic melanoma.

Br J Dermatol. 2016 Nov 21.  [Epub ahead of print]

Pawelec G.

Are Lower Antibody Responses to Influenza Vaccination in Cytomegalovirus-Seropositive Older Adults the Result of Beta Adrenergic Blockade?

Brain Behav Immun. 2016 Nov 16. pii: S0889-1591(16)30518-9.  [Epub ahead of print]

Shipp C, Speigl L, Janssen N, Martens A, Pawelec G.

A clinical and biological perspective of human myeloid-derived suppressor cells in cancer.

Cell Mol Life Sci. 2016 Nov;73(21):4043-61.  [PubMed]

Haq K, Fulop T, Tedder G, Gentleman B, Garneau H, Meneilly GS, Kleppinger A, Pawelec G, McElhaney JE.

Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status.

J Gerontol A Biol Sci Med Sci. 2016 Oct 27. pii: glw216.  [Epub ahead of print]

Janssen N, Fortis SP, Speigl L, Haritos C, Sotiriadou NN, Sofopoulos M, Arnogiannaki N, Stavropoulos-Giokas C, Dinou A, Perez S, Pawelec G, Baxevanis CN, Shipp C.

Peripheral T cell responses to tumour antigens are associated with molecular, immunogenetic and cellular features of breast cancer patients.

Breast Cancer Res Treat. 2016 Oct 27.  [Epub ahead of print]

Martens A, Wistuba-Hamprecht K, Yuan J, Postow MA, Wong P, Capone M, Madonna G, Khammari A, Schilling B, Sucker A, Schadendorf D, Martus P, Dreno B, Ascierto PA, Wolchok JD, Pawelec G, Garbe C, Weide B.

Increases in absolute lymphocytes and circulating CD4+ and CD8+ T cells are associated with positive clinical outcome of melanoma patients treated with ipilimumab.

Clin Cancer Res. 2016 Oct 1;22(19):4848-4858.   [PubMed]

Feinstein L, Douglas CE, Stebbins RC, Pawelec G, Simanek AM, Aiello AE.

Does cytomegalovirus infection contribute to socioeconomic disparities in all-cause mortality?

Mech Ageing Dev. 2016 Sep;158:53-61.  [PubMed]

Pawelec G.


Mech Ageing Dev. 2016 Sep;158:1-2.  [PubMed]

Janssen N, Derhovanessian E, Demuth I, Arnaout F, Steinhagen-Thiessen E, Pawelec G.

Responses of Dendritic Cells to TLR-4 Stimulation Are Maintained in the Elderly and Resist the Effects of CMV Infection Seen in the Young.

J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1117-23.  [PubMed]

Shipp C, Pawelec G.

The fifteenth International Conference on Progress in Vaccination against Cancer (PIVAC-15), 6-8 October 2015, Tübingen, Germany: looking back on 15 years of progress.

Cancer Immunol Immunother. 2016 Aug 24.  [Epub ahead of print]

Aiello AE, Feinstein L, Dowd JB, Pawelec G, Derhovanessian E, Galea S, Uddin M, Wildman DE, Simanek AM.

Income and Markers of Immunological Cellular Aging.

Psychosom Med. 2016 Jul-Aug;78(6):657-66.  [PubMed]

Wistuba-Hamprecht K, Martens A, Haehnel K, Geukes Foppen M, Yuan J, Postow MA, Wong P, Romano E, Khammari A, Dreno B, Capone M, Ascierto PA, Demuth I, Steinhagen-Thiessen E, Larbi A, Schilling B, Schadendorf D, Wolchok JD, Blank CU, Pawelec G, Garbe C, Weide B.

Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab.

Eur J Cancer. 2016 Jul 8;64:116-126.  [PubMed]

Fulop T, Witkowski JM, Le Page A, Fortin C, Pawelec G, Larbi A.

Intracellular signaling pathways: Targets to reverse immunosenescence.

Clin Exp Immunol. 2016 Jul 1.  [Epub ahead of print]

Tan CT, Wistuba-Hamprecht K, Xu W, Nyunt MS, Vasudev A, Lee BT, Pawelec G, Puan KJ, Rotzschke O, Ng TP, Larbi A.

Vδ2+ and a/ß T cells show divergent trajectories during human aging.

Oncotarget. 2016 Jun 15.  [Epub ahead of print]

Martens A, Wistuba-Hamprecht K, Geukes Foppen MH, Yuan J, Postow MA, Wong P, Romano E, Khammari A, Dreno B, Capone M, Ascierto PA, Di Giacomo AM, Maio M, Schilling B, Sucker A, Schadendorf D, Hassel JC, Eigentler TK, Martus P, Wolchok JD, Blank CU, Pawelec G, Garbe C, Weide B.

Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab.

Clin Cancer Res. 2016 Jun 15;22(12):2908-18.  [PubMed]

Kini Bailur J, Gueckel B, Pawelec G.

Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer.

J Transl Med. 2016 May 28;14(1):151.  [PubMed]

Brouwers B, Hatse S, Dal Lago L, Neven P, Vuylsteke P, Dalmasso B, Debrock G, Van Den Bulck H, Smeets A, Bechter O, Kini Bailur J, Kenis C, Laenen A, Schöffski P, Pawelec G, Journe F, Ghanem GE, Wildiers H.

The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters.

Oncotarget. 2016 May 24;7(21):29977-88.   [PubMed]

Aiello AE, Dowd JB, Jayabalasingham B, Feinstein L, Uddin M, Simanek AM, Cheng CK, Galea S, Wildman DE, Koenen K, Pawelec G.

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.

Psychoneuroendocrinology. 2016 May;67:133-141.  [PubMed]

Naumova E, Pawelec G, Mihaylova A.

Natural killer cells, ageing and cancer.

Cancer Immunol Immunother. 2016 Apr;65(4):367-70.  [PubMed]

Waaijer ME, Westendorp RG, Goldeck D, Gunn DA, Pawelec G, Stijntjes M, Slagboom PE, Maier AB.

Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?

Exp Gerontol. 2016 Apr 1. pii: S0531-5565(16)30088-2.  [Epub ahead of print]

Goldeck D, Witkowski JM, Fülop T, Pawelec G.

Peripheral immune signatures in Alzheimer Disease.

Curr Alzheimer Res. 2016;13(7):739-49. Epub 2016 Feb 21.  [PubMed]

Tegeler C, O'Sullivan JL, Bucholtz N, Goldeck D, Pawelec G, Steinhagen-Thiessen E, Demuth I.

The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function-data from the Berlin Aging Study II.

Neurobiol Aging. 2016 Feb;38:112-7.  [PubMed]

Goldeck D, Pawelec G, Norman K, Steinhagen-Thiessen E, Öttinger L, Hähnel K, Demuth I.

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort.

Biogerontology. 2016 Feb;17(1):189-98. Epub 2015 Apr 24.  [PubMed]

Maerz JK, Roncoroni LP, Goldeck D, Abruzzese T, Kalbacher H, Rolauffs B, DeZwart P, Nieselt K, Hart ML, Klein G, Aicher WK.

Bone Marrow-Derived Mesenchymal Stromal Cells Differ in their Attachment to Fibronectin-Derived Peptides from Term Placenta-Derived Mesenchymal Stromal Cells.

Stem Cell Res Ther. 2016 Feb 11;7(1):29.  [PubMed]

Wistuba-Hamprecht K, Di Benedetto S, Schilling B, Sucker A, Schadendorf D, Garbe C, Weide B, Pawelec G.

Phenotypic characterization and prognostic impact of circulating γδ and αβ T-cells in metastatic malignant melanoma.

Int J Cancer. 2016 Feb 1;138(3):698-704.  [PubMed]

Fulop T, Dupuis G, Baehl S, Le Page A, Bourgade K, Frost E, Witkowski JM, Pawelec G, Larbi A, Cunnane S.

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation.

Biogerontology. 2016 Feb;17(1):147-57.  [PubMed]

Gerstorf D, Bertram L, Lindenberger U, Pawelec G, Demuth I, Steinhagen-Thiessen E, Wagner GG.

Editorial: The Berlin Aging Study II - An Overview.

Gerontology. 2016;62(3):311-5. Epub 2016 Jan 29.  [PubMed]

Goldeck D, Oettinger L, Janssen N, Demuth I, Steinhagen-Thiessen E, Pawelec G.

Cytomegalovirus Infection Minimally Affects the Frequencies of B-Cell Phenotypes in Peripheral Blood of Younger and Older Adults.

Gerontology. 2016;62(3):323-9. Epub 2016 Jan 29.  [PubMed]

Chiu YL, Lin CH, Sung BY, Chuang YF, Schneck JP, Kern F, Pawelec G, Wang GC.

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4+ and CD8+ T-cell responses in older adults positively correlates with response size.

Sci Rep. 2016 Jan 18;6:19227.  [PubMed]

Goldeck D, Maetzler W, Berg D, Oettinger L, Pawelec G.

Altered dendritic cell subset distribution in patients with Parkinson's disease: Impact of CMV serostatus.

J Neuroimmunol. 2016 Jan 15;290:60-5.  [PubMed]


Wistuba-Hamprecht K, Haehnel K, Janssen N, Demuth I, Pawelec G.

Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II.

Immun Ageing. 2015 Dec 4;12:25.  [PubMed]

Wistuba-Hamprecht K, Pawelec G.

Characterization of γδ T-cells via flow cytometry.

Age (Dordr). 2015 Dec;37(6):123.  [PubMed]

Block KI, Gyllenhaal C, ... Pawelec G, ... Zollo M.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Semin Cancer Biol. 2015 Dec;35S:S276-S304.  [PubMed]

Vinay DS, Ryan EP, Pawelec G, Talib WH, Stagg J, Elkord E, Lichtor T, Decker WK, Whelan RL, Kumara HM, Signori E, Honoki K, Georgakilas AG, Amin A, Helferich WG, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Keith WN, Bhakta D, Halicka D, Fujii H, Aquilano K, Ashraf SS, Nowsheen S, Yang X, Choi BK, Kwon BS.

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

Semin Cancer Biol. 2015 Dec;35 Suppl:S185-98.  [PubMed]

Passtoors WM, van den Akker EB, Deelen J, Maier AB, van der Breggen R, Jansen R, Trompet S, van Heemst D, Derhovanessian E, Pawelec G, van Ommen GJ, Slagboom PE, Beekman M.

IL7R gene expression network associates with human healthy ageing.

Immun Ageing. 2015 Nov 11;12:21.  [PubMed]

Bailur JK, Derhovanessian E, Gueckel B, Pawelec G.

Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients.

J Immunother Cancer. 2015 Oct 20;3:45.  [PubMed]

McElhaney JE, Garneau H, Camous X, Dupuis G, Pawelec G, Baehl S, Tessier D, Frost EH, Frasca D, Larbi A, Fulop T.

Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes.

BMJ Open Diabetes Res Care. 2015 Oct 13;3(1):e000140.  [PubMed]

Di Benedetto S, Derhovanessian E, Steinhagen-Thiessen E, Goldeck D, Müller L, Pawelec G.

Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study.

Biogerontology. 2015 Oct;16(5):631-43.  [PubMed]

Buchmann N, Kassner U, Norman K, Goldeck D, Eckardt R, Pawelec G, Steinhagen-Thiessen E, Demuth I.

Higher Lipoprotein (a) Levels Are Associated with Better Pulmonary Function in Community-Dwelling Older People - Data from the Berlin Aging Study II.

PLoS One. 2015 Sep 30;10(9):e0139040.  [PubMed]

Teteloshvili N, Kluiver J, van der Geest KS, van der Lei RJ, Jellema P, Pawelec G, Brouwer E, Kroesen BJ, Boots AM, van den Berg A.

Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing.

PLoS One. 2015 Sep 11;10(9):e0137556. eCollection 2015.  [PubMed]

Pandha H, Pawelec G.

Immune checkpoint targeting as anti-cancer immunotherapy: promises, questions, challenges and the need for predictive biomarkers at ASCO 2015.

Cancer Immunol Immunother. 2015 Sep;64(9):1071-4.  [PubMed]

Müller L, Pawelec G.

As we age: Does slippage of quality control in the immune system lead to collateral damage?

Ageing Res Rev. 2015 Sep;23(Pt A):116-23.  [PubMed]

Derhovanessian E, Chen S, Maier AB, Hähnel K, de Craen AJ, Roelofs H, Westendorp R, Pawelec G.

CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):917-23.  [PubMed]

Fulop T, McElhaney J, Pawelec G, Cohen AA, Morais JA, Dupuis G, Baehl S, Camous X, Witkowski JM, Larbi A.

Frailty, Inflammation and Immunosenescence.

Interdiscip Top Gerontol Geriatr. 2015;41:26-40.  [PubMed]

Le Page A, Bourgade K, Lamoureux J, Frost E, Pawelec G, Larbi A, Witkowski JM, Dupuis G, Fülöp T.

NK Cells are Activated in Amnestic Mild Cognitive Impairment but not in Mild Alzheimer's Disease Patients.

J Alzheimers Dis. 2015  May 7;46(1):93-107.  [PubMed]

Bailur JK, Gueckel B, Derhovanessian E, Pawelec G.

Presence of circulating Her2-reactive CD8+ T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients.

Breast Cancer Res. 2015 Mar 10;17:34.  [PubMed]

Adriaensen W, Derhovanessian E, Vaes B, Van Pottelbergh G, Degryse JM, Pawelec G, Hamprecht K, Theeten H, Matheï C.

CD4:8 Ratio >5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results From the BELFRAIL Study.

J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):143-54.  [PubMed]

Zelba H, Weide B, Martens A, Bailur JK, Garbe C, Pawelec G.

The prognostic impact of specific CD4 T-cell responses is critically dependent on the target antigen in melanoma.

Oncoimmunology. 2015 Jan 30;4(1):e955683. eCollection 2015.  [PubMed]


Marthandan S, Robin Freeburn R, Steinbrecht S, Pawelec G, Barnett Y.
SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures.
Immun Ageing. 2014 Nov 30;11(1):17.  [PubMed]

Derhovanessian E, Maier AB, Hähnel K, McElhaney JE, Slagboom EP, Pawelec G.

Latent Infection with Cytomegalovirus Is Associated with Poor Memory CD4 Responses to Influenza A Core Proteins in the Elderly.

J Immunol. 2014 Oct 1;193(7):3624-31.  [PubMed]

Zelba H, Weide B, Martens A, Derhovanessian E, Kini Bailur J, Kyzirakos C, Pflugfelder A, Eigentler TK, Di Giacomo AM, Maio M, Aarntzen EH, de Vries IJ, Sucker A, Schadendorf D, Buttner P, Garbe C, Pawelec G.

Circulating CD4+ T-cells that produce IL-4 or IL-17 when stimulated by Melan-A but not by NY-ESO-1 have negative impacts on survival of stage IV melanoma patients. Clin Cancer Res. 2014 Aug 15;20(16):4390-9. [PubMed]

Pawelec G, Goldeck D, Derhovanessian E.

Inflammation, ageing and chronic disease.
Curr Opin Immunol. 2014 Aug;29:23-8.  [PubMed]

Weide B, Eigentler TK, Pflugfelder A, Zelba H, Martens A, Pawelec G, Giovannoni L, Ruffini PA, Elia G, Neri D, Gutzmer R, Becker JC, Garbe C.

Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19-IL2 Results in Sustained Clinical and Systemic Immunologic Responses.

Cancer Immunol Res. 2014 Jul;2(7):668-78. [PubMed]

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cicin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fülöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J.

New advances in CMV and immunosenescence.

Exp Gerontol. 2014 Jul;55:54-62.  [PubMed]

Müller L, Pawelec G.

Aging and immunity - impact of behavioral intervention.

Brain Behav Immun.  2014 Jul;39:8-22. [PubMed]

Wistuba-Hamprecht K, Pawelec G, Derhovanessian E.

OMIP-020: Phenotypic characterization of human γδ T-cells by multicolor flow cytometry.
Cytometry A. 2014 Jun;85(6):522-4. [PubMed]

Pawelec G.

Immunosensenescence: role of cytomegalovirus.

Exp Gerontol. 2014 Jun;54:1-5. [PubMed]

Faragher R, Frasca D, Remarque E, Pawelec G; for the ImAginE Consortium.

Better immunity in later life: a position paper.
Age (Dordr). 2014 Jun;36(3):9619. [PubMed]

Bertram L, Böckenhoff A, Demuth I, Düzel S, Eckardt R, Li SC, Lindenberger U, Pawelec G, Siedler T, Wagner GG, Steinhagen-Thiessen E.

Cohort Profile: The Berlin Aging Study II (BASE-II).

Int J Epidemiol. 2014 Jun;43(3):703-12.  [PubMed]

Fulop T, Witkowski JM, Pawelec G, Alan C, Larbi A.

On the immunological theory of aging.

Interdiscip Top Gerontol. 2014;39:163-76. [PubMed]

Pawelec G.

T-cell immunity in the aging human.
Haematologica. 2014 May;99(5):795-797. [PubMed]

Jones RP, Goldeck D.

Unexpected and unexplained increase in death due to neurological disorders in 2012 in England and Wales: Is cytomegalovirus implicated?
Med Hypotheses. 2014 Jul;83(1):25-31.  [PubMed]

Pallis AG, Hatse S, Brouwers B, Pawelec G, Falandry C, Wedding U, Lago LD, Repetto L, Ring A, Wildiers H.

Evaluating the physiological reserves of older patients with cancer: The value of potential biomarkers of aging?
J Geriatr Oncol. 2014 Apr;5(2):204-18.  [PubMed]

Weide B, Martens A, Zelba H, Stutz C, Derhovanessian E, Di Giacomo AM, Maio M, Sucker A, Schilling B, Schadendorf D, Büttner P, Garbe C, Pawelec G.

Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells.

Clin Cancer Res. 2014 Mar 15;20(6):1601-9. [PubMed]

Martens A, Zelba H, Garbe C, Pawelec G, Weide B.

Monocytic myeloid-derived suppressor cells in advanced melanoma patients: Indirect impact on prognosis through inhibition of tumor-specific T-cell responses?

Oncoimmunology. 2014 Jan 1;3(1):e27845. Epub 2014 Feb 14. [PubMed]

Turner JE, Campbell JP, Edwards KM, Howarth LJ, Pawelec G, Aldred S, Moss P, Drayson MT, Burns VE, Bosch JA.

Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults.

Age (Dordr). 2014 Feb;36(1):287-97. [PubMed]


Fulop T, Larbi A, Witkowski JM, Kotb R, Hirokawa K, Pawelec G.

Immunosenescence and cancer.

Crit Rev Oncog. 2013;18(6):489-513. [PubMed]

Fülöp T, Larbi A, Extermann M, Solana R, Dupuis G, Kotb R, Derhovanassian E, Pawelec G.

Aging, Immunosenescence, and Cancer. In: Rahman I, Bagchi D (eds). Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions 1edn. Academic Press, Oct 17 2013, p 55-69  [Link]

Buffa S, Pellicanò M, Bulati M, Martorana A, Goldeck D, Caruso C, Pawelec G, Colonna-Romano G.

A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24(-) B cells in centenarian offspring and elderly people.

Age (Dordr). 2013 Oct;35(5):2009-24  [PubMed]

Ioannoua K, Derhovanessian E, Tsakiric E, Samaraa P, Kalbacher H, Voelter W, Trougakosc I, Pawelec G, Tsitsilonisa OE.

Prothymosin α and a prothymosin α-derived decapeptide induce ΤH1-type tumor-specific immune responses via ligating Toll-like receptor-4.

BMC Immunol. 2013 Sep 22;14:43. [PubMed]

Fülöp T, Larbi A, Pawelec G.
Human T cell aging and the impact of persistent viral infections.
Front Immunol. 2013 Sep 13;4:271  [PubMed]

Alam I, Goldeck D, Larbi A, Pawelec G.
Aging affects the proportions of T and B cells in a group of elderly men in a developing country—a pilot study from Pakistan.

Age (Dordr). 2013 Oct;35(5):1521-30  [PubMed]

Dahl C, Christensen C, Jonsson G, Lorentzen A, Skjodt ML, Borg A, Pawelec G, Guldberg P.

Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14ARF and retinoic acid receptor β signaling.

Mol Cancer Res. 2013 Oct;11(10):1166-78  [PubMed]

Pellicanò M, Buffa S, Goldeck D, Bulati M, Martorana A, Caruso C, Colonna-Romano G, Pawelec G.

Evidence for Less Marked Potential Signs of T-Cell Immunosenescence in Centenarian Offspring Than in the General Age-Matched Population.

J Gerontol A Biol Sci Med Sci. 2013 Aug 24  [PubMed]

Goldeck D, Larbi A, Pellicanó M, Alam I, Zerr I, Schmidt C, Fulop T, Pawelec G.

Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's Disease.

PLoS One. 2013 Jun 18;8(6):e66664. Print 2013 [PubMed]

Wistuba-Hamprecht K, Frasca D, Blomberg B, Pawelec G, Derhovanessian E.

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus.

Immun Ageing. 2013 Jul 3;10(1):26.  [PubMed]

Müller L, Fülöp T, Pawelec G.

Immunosenescence in vertebrates and invertebrates.

Immun Ageing. 2013 Apr 2;10(1):12.  [PubMed]

Shipp C, Weide B, Derhovanessian E, Pawelec G.

Hsps are up-regulated in melanoma tissue and correlate with patient clinical parameters.

Cell Stress Chaperones. 2013 Mar;18(2):145-54  [PubMed]

Goldeck D, Low I, Shadan NB, Mustafah S, Pawelec G, Larbi A.

Multi-parametric phospho-flow cytometry: A crucial tool for T lymphocyte signaling studies. Cytometry A. 2013 Mar;83(3):265-72  [PubMed]

Marthandan S, Hyland P, Pawelec G, Barnett Y.

An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine
on human peripheral blood mononuclear cells and T cells.

Immun Ageing. 2013 Feb 21;10(1):7  [PubMed]

Naumova E, Ivanova M, Pawelec G, Constantinescu I, Bogunia-Kubik K, Lange A, Oguz F, Ozdilli K, Franceschi C, Caruso C, Mishra M, Middleton D.

16(th) IHIW: Immunogenetics of Aging.

Int J Immunogenet. 2013 Feb;40(1):77-81  [PubMed]

Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE.

Gene expression analysis of mTOR pathway: association with human longevity.

Aging Cell. 2013 Feb;12(1):24-31  [PubMed]

Fülöp T, Lacombe G, Cunnane S, Le Page A, Dupuis G, Frost EH, Bourgade-Navarro K, Goldeck D, Larbi A, Pawelec G.

Elusive Alzheimer's Disease: Can Immune Signatures Help Our Understanding of This Challenging Disease? Part 1: Clinical and Historical Background.

Discov Med. 2013 Jan;15(80):23-32  [PubMed]

Part 2: New Immune Paradigm.

Discov Med. 2013 Jan;15(80):33-42  [PubMed]

Kurnick JT, Pandolfi F and Pawelec G.

Current Challenges in Immunology.

ITI 2013; 1(1): 5-9, Jan 2013  [PubMed]

Derhovanessian E, Theeten H, Hähnel K, Van Damme P, Cools N, Pawelec G.

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.

Vaccine. 2013 Jan 11;31(4):685-90  [PubMed]

Calder PC, Ahluwalia N, Albers R, Bosco N, Bourdet-Sicard R,Haller D, Holgate ST, Jönsson LS, Latulippe ME, Marcos A,Moreines J, M’Rini C, Müller M, Pawelec G, van Neerven RJJ,Watzl B and Zhao J.: A Consideration of Biomarkers to be used for Evaluation of Inflammation in Human Nutritional Studies.

Br J Nutr. 2013 Jan;109 Suppl 1:S1-S34. [PubMed].

Fülöp T, Larbi A, Kotb R, Pawelec G.

Immunology of aging and cancer development.

Interdiscip Top Gerontol. 2013;38:38-48  [PubMed]


Alam I, Alam I, Paracha PI, Pawelec G.

Higher estimates of daily dietary net endogenous acid production (NEAP) in the elderly as compared to the young in a healthy, free-living elderly population of Pakistan.

Clinical Interventions in Aging. Dec 2012; Vol 2012:7; p.565 - 573  [PubMed]


Bot A, Ahn M, Bosch M, Brockstedt D, Butterfield LH, Cornforth A, Harrop R, Kast WM, Koya R, Marincola F, Margolin K, McCoy C, Pawelec G, Rothman J, Schlom J, Srivastava P, Wallis S, Walter S, Wang E, Waslif J.

A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies.

J Transl Med. 2012 Nov 5;10(1):218  [PubMed]


Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zielinski M, Pawelec G.

CMV and Immunosenescence: from basics to clinics.

Immun Ageing. 2012 Oct 31;9(1):23  [PubMed]


Galon J, Franck P, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F, Britten CM, Kreiter S, Chouchane L, Delrio P, Hartmann A, Asslaber M, Maio M, Masucci GV, Mihm M, Vidal-Vanaclocha F, Allison JP, Gnjatic S, Hakansson L, Huber C, Singh-Jasuja H, Ottensmeier C, Zwierzina H, Laghi L, Grizzi F, Ohashi PS, Shaw PA, Clarke BA, Wouters BG, Kawakami Y, Hazama S, Okuno K, Wang E, O'Donnell-Tormey J, Lagorce C, Pawelec G, Nishimura MI, Hawkins R, Lapointe R, Lundqvist A, Khleif SN, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Palmqvist R, Nagtegaal ID, Wang Y, D'Arrigo C, Kopetz S, Sinicrope FA, Trinchieri G, Gajewski TF, Ascierto PA, Fox BA.

Cancer classification using the Immunoscore: a worldwide task force.

J Transl Med. 2012 Oct 3;10(1):205  [PubMed]


Jensen-Jarolim E, Pawelec G.

The nascent field of AllergoOncology.

Cancer Immunol Immunother. 2012 Sep;61(9):1355-7  [PubMed]

Alam I, Pawelec G.

Aging, nutrition and immunity – their relationship and interaction.
Nutrition and Aging 2012, 1(3): 151-165.

Chen S, de Craen A, Raz Y, Derhovanessian E, Vossen A, Rudi W, Pawelec G, Maier A.

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study.

Immun Ageing. 2012 Aug 28;9(1):18  [PubMed]

Alam I, Larbi A, Pawelec G.

Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan.

Immunity & Ageing 2012, 9:16  [PubMed]


Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M, Brugger W, Dietrich PY, Mendrzyk R, Hilf N, Schoor O, Fritsche J, Mahr A, Maurer D, Vass V, Trautwein C, Lewandrowski P, Flohr C, Pohla H, Stanczak JJ, Bronte V, Mandruzzato S, Biedermann T, Pawelec G, Derhovanessian E, Yamagishi H, Miki T, Hongo F, Takaha N, Hirakawa K, Tanaka H, Stevanovic S, Frisch J, Mayer-Mokler A, Kirner A, Rammensee HG, Reinhardt C, Singh-Jasuja H.

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival.

Nat Med. 2012 Aug;18(8):1254-61  [PubMed]


C.M. Britten, S. Janetzk, L.H. Butterfield, G. Ferrari, C. Gouttefangeas, C. Huber, M. Kalos, H.I. Levitsky, H.T. Maecker, C.J.M. Melief, J. O’Donnell-Tormey, K. Odunsi, L.J. Old, T.H.M. Ottenhoff, C. Ottensmeier, G. Pawelec, M. Roederer, B.O. Roep, P. Romero, S.H. van der Burg, S. Walter, A. Hoos, M.M. Davis. (Letter)

T Cell Assays and MIATA: The Essential Minimum for Maximum Impact

Immunity. 2012 Jul 27;37(1):1-2 [PubMed]


Pawelec G. (Editorial)
Hallmarks of human "immunosenescence": adaptation or dysregulation?
Immunity & Ageing 2012 Jul 25;9(1):15. [PubMed]


Alam I, Goldeck D, Larbi A, Pawelec G.

Aging affects the proportions of T and B cells in a group of elderly men in a developing country-a pilot study from Pakistan.

Age (Dordr). Epub 2012 Jul 19  [PubMed]


Shipp C, Derhovanessian E, Pawelec G.

Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines.

PLoS One. 2012;7(6):e37475. Epub 2012 Jun 22  [PubMed]


Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, Slagboom EP, Westendorp RG, Pawelec G.

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people.

Age (Dordr). 2013 Aug;35(4):1387-99. Epub 2012 Jun 4.  [PubMed]


Weide B, Zelba H, Derhovanessian E, Pflugfelder A, Eigentler TK, Di Giacomo AM, Maio M, Aarntzen EH, de Vries IJ, Sucker A, Schadendorf D, Büttner P, Garbe C, Pawelec G.

Functional T Cells Targeting NY-ESO-1 or Melan-A Are Predictive for Survival of Patients With Distant Melanoma Metastasis.

J Clin Oncol. 2012 May 20;30(15):1835-41  [PubMed]


Alam I, Goldeck D, Larbi A, Pawelec G.

Flow cytometric lymphocyte subset analysis using material from frozen whole blood.

J Immunoassay Immunochem. 2012 Apr;33(2):128-39  [PubMed


Pawelec G, McElhaney JE, Aiello AE, Derhovanessian E.

The impact of CMV infection on survival in older humans.

Curr Opin Immunol 2012 Apr 26  [PubMed]


McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G.

The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.

Vaccine. 2012 Mar 9;30(12):2060-7  [PubMed]

Ioannou K, Samara P, Livaniou E, Derhovanessian E, Tsitsilonis OE.

Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy.

Cancer Immunol Immunother. 2012 May;61(5):599-614  [PubMed]

Pellicanò M, Larbi A, Goldeck D, Colonna-Romano G, Buffa S, Bulati M, Rubino G, Iemolo F, Candore G, Caruso C, Derhovanessian E, Pawelec G.

Immune profiling of Alzheimer patients.

J Neuroimmunol. 2012 Jan 18;242(1-2):52-9  [PubMed]