• Heinzel S, Rea D, Offringa R, Pawelec G: Human CD4+ T cells sensitized to Annexin II (208-223) recognize melanoma cells over-expressing the Annexin II protein. Cancer Immunol Immunother 49:671, 2001
  • Müller L, Provenzani C, Faul C, Pawelec G: Recognition of chronic myelogenous leukaemia cells by autologous T lymphocytes primed in vitro against the patient´s dendritic cells. B J Haematol 112: 740, 2001
  • Hyland P, Barnett C, Pawelec G, Barnett Y: Increased levels of oxidative DNA damage and alterations in the levels of the mitotic inhibitors p16INK4a/CDKN2a, p21WAF1/CIP1/SDI1, p27KIP1 leads to T cell replicative senescence in vitro. Mech Ageing Dev 122:1151, 2001
  • Müller L, Provenzani C, Pawelec G: Generation of CML-specific T cells in cytokine-modified autologous mixed lymphocyte/tumour cell cultures. J Immunother 24:482, 2001
  • Ross OA, Hyland P, Curran MD, McIlhatton BP, Wikby A, Johansson B, Tompa A, Pawelec G, Barnett CR, Middleton D, Barnett YA: Mitochondrial DNA damage in lymphocytes: a role in immunosenescence? Exp Gerontol 37:329, 2002
  • Pawelec G, Barnett Y, Mariani E, Solana R: Human CD4+ T cell clone longevity in tissue culture: lack of influence of donor age or cell origin. Exp Gerontol 37:265, 2002
  • Knights AJ, Zaniou A, Rees RC, Pawelec G, Müller L: Prediction of an HLA-DR-binding peptide derived from Wilms' tumour1 protein and demonstration of in vitro immunogenicity of WT1(124- 138)-pulsed dendritic cells generated according to an optimised protocol. Cancer Immunol Immunother 51:271, 2002
  • Wagner W, Ouyang Q, Pawelec G: Peptides spanning the fusion region of Abl/Bcr are immunogenic and sensitize CD8(+) T lymphocytes to recognize native chronic myelogenous leukemia. Leukemia 16:2341, 2002
  • Knights A, Müller L, Pawelec G: Immunogenicity of WT-1 peptides. Cancer Immunol Immunother 51:349, 2002
  • Müller L, Knights A, Pawelec G: Synthetic peptides derived from the Wilms´ tumor 1 protein sensitize human T lymphocytes to recognize chronic myelogenous leukemia cells. Hematol J 4:57-66, 2003
  • Wagner W, Ouyang Q, Pawelec G: The abl/bcr gene product as a novel leukemia-specific antigen: peptides spanning the fusion region of abl/bcr can be recognized by both CD4(+) and CD8(+) T lymphocytes. Cancer Immunol Immunother. 52:89, 2003
  • Ouyang Q, Wagner WM, Walter S, Müller CA, Wikby A, Aubert G, Klatt T, Stevanovic S, Dodi T, Pawelec G: The age-related increase in CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counterbalanced by decreased antigen-specific responsiveness. Mech Ageing Dev 124: 477, 2003
  • Ouyang Q, Wagner W, Wikby A, Walter S, Aubert G, Dodi T, Travers P, Pawelec G: Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 23:247-257, 2003
  • Ouyang Q, Wagner WM, Voehringer D, Wikby A, Klatt T, Walter S, Müller CA, Pircher H, Pawelec G: Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp Gerontol 38:911-920, 2003
  • Flad T, Schiestel T, Brunner H, Tolson J, Ouyang Q, Pawelec G, Mueller GA, Mueller CA, Tovar GE, Beck H. Development of an MHC-class I peptide selection assay combining nanoparticle technology and matrix-assisted laser desorption/ionisation mass spectrometry. J Immunol Methods. 283:205- 213, 2003
  • Neri S, Cattini L, Facchini A, Pawelec G, Mariani E: Microsatellite instability in in vitro ageing of T lymphocyte clones. Exp Gerontol 39:499-505, 2004
  • Krichevsky S, Pawelec G, Gural A, Effros RB, Globerson A, Ben Yehuda D, Ben Yehuda A: Age- related microsatellite instability in T cells from healthy individuals. Exp Gerontol 39:507-515, 2004
  • Duggan O, Hyland P, Annett K, Freeburn R, Barnett C, Pawelec G, Barnett Y: Effects of a reduced oxygen tension culture system on human T cell clones as a function of in vitro age. Exp Gerontol 39:525-530, 2004
  • Della Valle NS, Bárcia RN, Pawelec G, McLeod JD: Activation marker expression and apoptotic susceptibility of T cell clones derived from CD34+, young and SENIEUR donors. Exp Gerontol 39:531- 538, 2004
  •  Ouyang Q, Wagner WM, Zheng W, Wikby A, Remarque EJ, Pawelec G: Dysfunctional CMV-specific CD8+ T cells accumulate in the elderly. Exp Gerontol 39:607-613, 2004
  • Schmolz M, Hurst TL, Bailey DM, Powell JR, Forsey RJ, Thompson JM, Williams C, Pawelec G: Validation of a new highly standardised, lab-independent whole-blood leukocyte function assay for clinical trials (ILCS®). Exp Gerontol 39:667-671, 2004
  • Rodriguez T, Mendez R, Roberts CH, Ruiz-Cabello F, Dodi IA, Nevot MA, Paco L, Maleno I, Marsh SG, Pawelec G, Garrido F. High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity. Cancer Immunol Immunother. 54: 141-148, 2005
  • Klatt T, Ouyang Q, Flad T, Koetter I, Buhring HJ, Kalbacher H, Pawelec G, Muller CA. Expansion of peripheral CD8+ CD28- T cells in response to Epstein-Barr virus in patients with rheumatoid arthritis. J Rheumatol. 32: 239-251, 2005
  • Wikby A, Ferguson F, Forsey R, Thompson J, Strindhall J, Löfgren S, Nilsson B-O, Ernerudh J,Pawelec G, Johansson B: An immune risk phenotype, cognitive impairment and survival in very late life: The impact of allostatic load in Swedish Octo- and Nonagenarian humans. J Gerontol B 60: 556- 565, 2005
  • Walter S, Boley G, Bühring H-J, Koch S, Wernet D, Zippelius A, Pawelec G, Romero P, Stevanović S, Rammensee H-G, Gouttefangeas C: High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors. Eur J Immunol 35: 2876-2885, 2005
  • Annett K, Duggan O, Freeburn R, Hyland P, Pawelec G, Barnett Y. An investigation of DNA mismatch repair capacity under normal culture conditions and under conditions of supra- physiological challenge in human CD4+T cell clones from donors of different ages. Exp Gerontol. 40:976-981, 2005
  • Reker-Hadrup S, Strindhall J, Køllgaard T, Seremet T, Johansson B, Pawelec G, thor Straten P, Wikby A. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional CMV specific T cells in the very elderly. J Immunol 176:2645-2653, 2006
  • Pawelec G, Marsh S. ESTDAB: a collection of immunologically-characterised melanoma cell lines and searchable databank. Cancer Immunol Immunother 55:623-627, 2006
  • Knights A, Weinzierl A, Flad T, Guinn B, Müller L, Mufti G, Stevanovic S, Pawelec G: A novel MHC- associated Proteinase 3 peptide isolated from primary CML cells further supports the significance of this antigen for immunotherapy of myeloid leukaemias. Leukemia 20:1067-1072, 2006
  • Wikby A, Nilsson BO, Forsey R, Thompson J, Strindhall J, Lofgren S, Ernerudh J, Pawelec G, Ferguson F, Johansson B.The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech Ageing Dev.127:695-704, 2006 87)
  • Mazzatti DJ, White A, Forsey RJ, Powell JR, Pawelec G: Gene expression changes in long- term culture of T-cell clones: Genomic effects of chronic antigenic stress in ageing and immunosenescence. Aging Cell 6:155-163, 2007
  • Neri S, Pawelec G, Facchini A, Mariani E: Microsatellite Instability and compromized Mismatch Repair gene expression during in vitro passaging of monoclonal human T lymphocytes. Rej Res 10:145-56, 2007
  • Nikolova PN, Pawelec G, Mihailova SM, Ivanova MI, Myhailova AP, Baltadjieva DN, Marinova DI, Ivanova SS, Naumova EJ. Association of cytokine gene polymorphisms with malignant melanoma in the Caucasian population. Cancer Immunol Immunother. 56:371-379, 2007
  • Trougakos IP, Pawelec G, Tzavelas C, Ntouroupi T, Gonos ES: Clusterin/Apolipoprotein J up- regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cells. Biogerontology 7:375-382, 2006
  • Rodriguez T, Mendez R, Del Campo A, Aptsiauri N, Martin J, Orozco G, Pawelec G, Schadendorf D, Ruiz-Cabello F, Garrido F. Patterns of constitutive and IFN-gamma inducible expression of HLA class II molecules in human melanoma cell lines. Immunogenetics 59: 123-133, 2007
  • Colonna-Romano G, Akbar AN, Aquino A, Bulati M, Candore G, Lio D, Ammatuna P, Fletcher JM, Caruso C, Pawelec G. Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily. Exp Gerontol. 42: 995-1002, 2007
  • Britten CM, Gouttefangeas C, Welters MJ, Pawelec G, Koch S, Ottensmeier C, Mander A, Walter S, Paschen A, Muller-Berghaus J, Haas I, Mackensen A, Kollgaard T, Thor Straten P, Schmitt M, Giannopoulos K, Maier R, Veelken H, Bertinetti C, Konur A, Huber C, Stevanovic S, Wolfel T, van der Burg SH. The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen- specific CD8(+) T lymphocytes by structural and functional assays. Cancer Immunol Immunother. 57: 289-302, 2008
  • Strindhall J, Nilsson BO, Lofgren S, Ernerudh J, Pawelec G, Johansson B, Wikby A. No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp Gerontol. 42: 753-761, 2007
  • Larbi A, Kempf J, Pawelec G. Oxidative stress modulation and T cell activation. Exp Gerontol. 42: 852-858, 2007
  • Mathieu MG, Knights AJ, Pawelec G, Riley CL, Wernet D, Lemonnier FA, Straten PT, Mueller L, Rees RC, McArdle SE. HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides. Cancer Immunol Immunother. 56: 1885-1895, 2007
  • Mazzatti DJ, Pawelec G, Longdin R, Powell JR, Forsey RJ. SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence. Proteome Sci. Jun 5;5:7, 2007
  • Méndez R, Rodríguez T, Del Campo A, Monge E, Maleno I, Aptsiauri N, Jiménez P, Pedrinaci S, Pawelec G, Ruiz-Cabello F, Garrido F. Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines. Cancer Immunol Immunother. 57: 719-729, 2008
  • Neri S, Pawelec G, Facchini A, Ferrari C, Mariani E. Altered Expression of Mismatch Repair Proteins Associated with Acquisition of Microsatellite Instability in a Clonal Model of Human T Lymphocyte Aging. Rejuvenation Res. 11: 565-572, 2008
  • Koch S, Larbi A, Derhovanessian E, Ozcelik D, Naumova E, Pawelec G. Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing;5:6, 2008
  • Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee H-G, Steinle A. NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood 113:358-369, 2009
  • Larbi A, Pawelec G, Witkowski J, Schipper H, Derhovanessian E, Fülöp T. Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer´s disease. J Alzheimer´s Disease 17:91- 103, 2009
  • Casado JG, Delarosa O, Pawelec G, Peralbo E, Duran E, Barahona F, Solana R, Tarazona R. Correlation of effector function with phenotype and cell division after in vitro differentiation of naive MART-1-specific CD8+ T cells. Int Immunol. 21:53-62, 2009
  • Skopeliti M, Iconomidou VA, Derhovanessian E, Pawelec G, Voelter W, Kalbacher H, Hamodrakas SJ, Tsitsilonis OE. Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner. Mol Immunol. 46:784-792, 2009
  • Robinson J, Roberts CH, Dodi IA, Madrigal JA, Pawelec G, Wedel L, Marsh SG: The European searchable tumour line database. Cancer Immunol Immunother. 58:1501-1506, 2009
  • Derhovanessian E, Adams V, Hähnel K, Groeger A, Pandha H, Ward S, Pawelec G: Pre-treatment frequency of circulating IL-17+CD4+ T-cells, but not Tregs, correlates with clinical response to whole- cell vaccination in prostate cancer patients. Int J Cancer 125:1372-1379, 2009
  • Casado JG, Pawelec G, Morgado S, Sanchez-Correa B, Delgado E, Gayoso I, Duran E, Solana R, Tarazona R: Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines. Cancer Immunol Immunother. 58:1517-1526, 2009
  • Weide B, Pascolo S, Scheel B, Derhovanessian E, Pflugfelder A, Eigentler TK, Pawelec G, Hoerr I, Rammensee HG, Garbe C: Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J Immunother. 32:498-507, 2009
  • Attig S, Hennenlotter J, Pawelec G, Klein G, Koch S, Pircher H, Feyerabend S, Wernet D, Stenzl A, Rammensee HG, Gouttefangeas C: Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas. Cancer Res 69:8412-8419, 2009
  • Larbi A, Cabreiro F, Zelba H, Marthandan S, Combet E, Friguet B, Petropoulos I, Barnett Y, Pawelec G: Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radic Biol Med. 48:26, 2010
  • Larbi A, Zelba H, Goldeck D, Pawelec G. Induction of HIF-1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells. J. Leuk. Biol. 87:265, 2010
  • Uddin M, Aiello AE, Wildman DE, Koenen KC, Pawelec G, de los Santos R, Goldmann E, Galea S: Epigenetic and immune function profiles associated with post-traumatic stress disorder. PNAS 107:9470-9475, 2010
  • Kamphausen E, Kellert C, Abbas T, Akkad N, Tenzer S, Pawelec G, Schild H, van Endert P, Seliger B: Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma. Cancer Immunol Immunother. 59:1273-1284, 2010
  • Weide B, Derhovanessian E, Pflugfelder A, Eigentler TK, Radny P, Zelba H, Pföhler C, Pawelec G, Garbe C: High response rate and prolonged survival after intratumoral treatment with interleukin-2 – results of a phase II DeCOG-study in 51 metastasized melanoma patients. Cancer 116: 4139-4146, 2010
  • Derhovanessian E, Maier AB, Beck R, Jahn G, Hähnel K, Slagboom PE, De Craen AJM, Westendorp RGJ, Pawelec G: Hallmark features of immunosenescence are absent in familial longevity. J Immunol 185:4618-4624, 2010