EUCAPS - European Union Concerted Action on Peptide Sensitization

Concerted Action coordinated by G. Pawelec

BMH4-CT98-3058 (1998-2001)

 

EUCAPS is the European Union Concerted Action on Peptide Sensitization with the purpose of developing improved methods for in vitro sensitization of human T cells to synthetic tumour antigens in vitro and their use in adoptive immunotherapy of cancer. EUCAPS is supported by the EC through contract number BMHI-CT98-3058. It began in March 1998 and will run for 3 years.

Objectives

  • To identify novel human tumour antigens and to synthesize peptides maximising their recognition by T cells.
  • To optimize and standardize peptide sensitization protocols for MHC class II as well as class I-restricted T cell responses.
  • To demonstrate recognition of native tumour cells by peptide-sensitized T cells and to control tumour cell growth in vitro and eventually in vivo.