EUCAPS

European Union Concerted Action on Peptide Sensitization

Concerted Action coordinated by G. Pawelec

EUCAPS is the European Union Concerted Action on Peptide Sensitization with the purpose of developing improved methods for in vitro sensitization of human T cells to synthetic tumour antigens in vitro and their use in adoptive immunotherapy of cancer. EUCAPS is supported by the EC through contract number BMHI-CT98-3058. It began in March 1998 and will run for 3 years.


Objectives

  • To identify novel human tumour antigens and to synthesize peptides maximising their recognition by T cells.
  • To optimize and standardize peptide sensitization protocols for MHC class II as well as class I-restricted T cell responses.
  • To demonstrate recognition of native tumour cells by peptide-sensitized T cells and to control tumour cell growth in vitro and eventually in vivo.